Adult-Gerontology Clinical Nurse Specialist (CNS) Practice Exam

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What is characterized by a delay in absorption of a drug in older adults?

Preclinical phase
Metabolic rate
Physiological changes
Distribution mechanics

The correct answer is: Physiological changes

The correct answer highlights that physiological changes in older adults can significantly impact various aspects of pharmacokinetics, including drug absorption. As individuals age, several physiological changes occur, such as decreased gastric acid production, slowed gastric emptying, and alterations in gastrointestinal motility. These factors can lead to a delay in the absorption of medications, as the time it takes for a drug to reach systemic circulation may be prolonged. In older adults, the integrity of the gastrointestinal tract may also be affected, further complicating the absorption process. Understanding these physiological changes is crucial for healthcare providers in order to adjust medication doses or timing, ensuring effective treatment outcomes while minimizing potential side effects. Other options, while relevant to pharmacotherapy in older populations, do not specifically address the delays in drug absorption caused by age-related physiological changes.