Adult-Gerontology Clinical Nurse Specialist (CNS) Practice Exam

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Which of the following is an absolute contraindication for estrogen replacement therapy?

  1. Endometriosis

  2. Recent myocardial infarction

  3. Hypertension

  4. Gallstones

The correct answer is: Recent myocardial infarction

Estrogen replacement therapy is contraindicated in certain conditions due to the increased risk of serious health complications. A recent myocardial infarction represents a significant risk factor where estrogen therapy can exacerbate cardiovascular problems. Estrogen can contribute to blood clot formation and may lead to further cardiovascular events in individuals with a history of myocardial infarction. Therefore, administering estrogen replacement therapy in this scenario could pose a life-threatening risk, making it an absolute contraindication. In contrast, while endometriosis, hypertension, and gallstones can be concerns when considering estrogen therapy, they do not serve as absolute contraindications. For instance, endometriosis may require careful management rather than outright avoidance of estrogen, while hypertension can be controlled, and gallstones do not have an established direct contraindication with estrogen therapy. Thus, the risk associated with a recent myocardial infarction makes it a critical factor in determining eligibility for estrogen replacement therapy.

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